First-Person Neuroscience: A new methodological approach for linking mental and neuronal states

Table 1 Signal changes as obtained in categorical or third-person and parametric or first-person analysis.

	Signal changes in categorical analysis (third-person)	Signal changes in parametric analysis (first-person)
Orbitomedial prefrontal cortex (OMPFC)	-2/54/14, 3.65	16/56/19, 3.35
Dorsomedial prefrontal cortex (DMPFC)	4/48/40, 3.68	12/48/24, 3.29
Medial parietal cortex (MPC)	-	-2/-34/60, 3.68
Insula	-	-54/-10/14, 4.32
Bilateral posterior parietal cortex	-48/-67/28, 3.36; 50/-63/25, 3.34	-
Thalamus/Hypothalamus	0/-8/4, 3.39	-
Posterior cingulate	0/-38/40, 3.83	-

X, y, z: MNI coordinates in mm. X describes right (+)/left (-), y anterior (+)/posterior (-), and z superior (+)/inferior (-) distances (e.g. 21/23/43, 3.45 ≅ x = 21/y = 23/z = 43, Z = 3.45). Coordinates of the local maxima of regional signal increases are given. Z = Z-score. Only signal increases with Z > 3.29 (p < 0.001, uncorrected, voxel level) are described.
Signal changes associated with categorical analysis reflect the comparison between the IAPS picture categories and the baseline condition. (Left column)
In contrast, the parametric analysis tested for a linear relationship between regional changes in the BOLD signal and valence of the presented IAPS pictures as rated by the investigated subjects. The IAPS pictures were modeled as a regressor according to their valence ranging from 1 to 9. The parametric signal changes were tested against the baseline condition. Regions are listed that show a positive linear relationship between valence and BOLD signal changes. (Right column)
Note the overlap between both comparisons with regard to involvement of OMPFC and DMPFC. The other regions, in contrast, were either involved in categorical or parametric analysis.

ISSN: 1747-5341