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Table 4 Selected historical examples of interventions widely endorsed and seldom contested that are not based on any evidence from randomized trials. (Adapted from [63])

From: The need to reform our assessment of evidence from clinical trials: A commentary

Blood transfusion for severe hemorrhagic shock
Defibrillation for ventricular fibrillation or pulseless ventricular tachycardia
Neostigmine for myasthenia gravis
Suturing for repair of large wounds
Closed reduction/splinting for displaced long-bone fractures
Insulin for diabetes mellitus
Directed pressure/suturing to stop bleeding
Activated charcoal for strychnine poisoning