From: Should We Treat Depression with drugs or psychological interventions? A Reply to Ioannidis
 | Percent Relapse |  | |||
---|---|---|---|---|---|
Maintenance Studies | Drug | Placebo | Difference | Ratio/drug | Reference |
Early 1953-1976 | 27% | 53% | -26% | 2.0 | [29] |
Three Year Treatment imipramine | 30% | 72% | -47% | 3.4 | |
Imipramine group from 3 year study randomized to drug or placebo yr. 4-5. | 10% | 67% | -57% | 6.7 | |
Later 1953-2003 | 18% | 41% | -23% | 2.3 | [30] |
Later 1998-2006 | 23% | 50% | -27% | 2.2 | [32] |