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Table 2 summarizes the percent of patients relapsing on placebo or drug in several meta-analyses and from one individual NIMH supported 5-year study.

From: Should We Treat Depression with drugs or psychological interventions? A Reply to Ioannidis

  Percent Relapse  
Maintenance Studies Drug Placebo Difference Ratio/drug Reference
Early 1953-1976 27% 53% -26% 2.0 [29]
Three Year Treatment imipramine 30% 72% -47% 3.4 [22, 23, 33]
Imipramine group from 3 year study randomized to drug or placebo yr. 4-5. 10% 67% -57% 6.7 [22, 23, 33]
Later 1953-2003 18% 41% -23% 2.3 [30]
Later 1998-2006 23% 50% -27% 2.2 [32]